Development of Renal Vasculature

Kidney neurovascular networks are critical to maintaining mammalian physiology and homeostasis. Despite their important roles, we know little about how they form and pattern in the embryonic kidney or how neurovascular interactions affect kidney development. Netrin-1 (Ntn1) is a secreted ligand critical for neurovascular guidance during embryogenesis and is highly expressed by stromal progenitors. Therefore, netrin-1 is an ideal candidate for regulating these processes during kidney development. In turn, the neurovascular networks can release factors important for development and maturation of tissues. We set out to identify candidate angiocrine factors released by the kidney endothelium and confirm their role in renal development.

Kidney vasculature

Publication

Honeycutt, S.E. and O’Brien L.L. 2020. Injection of Evans blue dye to fluorescently label and image intact vasculature. Biotechniques. 2020. doi: 10.2144/btn-2020-0152.