2025
McLarnon SR, Honeycutt SE, N’Guetta PY, Xiong Y, Xinwei L, Abe K, Kitai H, Souma T, O’Brien LL. 2025. Altered renal vascular patterning reduces ischemic kidney injury and limits age-associated vascular loss. Am J Physiol Renal Physiol. DOI: 10.1152/ajprenal.00284.2024
Peng Z, Vanichapol T, Nguyen PD, Chang GHH, Kocha KM, O’Brien LL, Currie PD, Huang P, Davidson AJ. 2025. Somites are a source of nephron progenitors in zebrafish. bioRxiv. doi.org/10.1101/2025.04.15.649022
Lin J, Marin Z, Wang X, Borges HM, N’Guetta PY, Luo X, Porter BA, Xue Y, Islam MT, Ngo T, Aurora AB, Zhao H, Conzen SD, Morrison SJ, Liang S, Zhong Z, O’Brien LL, Dean KM. 2025. Feature-Driven Whole-Tissue Imaging with Subcellular Resolution. bioRxiv. DOI: 10.1101/2025.01.23.634600
2024
O’Brien LL. 2024. Enhancing kidney organoid maturity with inducible vascularization: another step forward for in vitro modeling. Kidney International. DOI: 10.1016/j.kint.2024.09.013
Gerlach G, Xiong Y, O’Brien LL. 2024. The tricellular junctional protein Ildr2 helps maintain glomerular podocyte architecture. bioRxiv. doi.org/10.1101/2024.05.03.592393
N’Guetta PY, McLarnon SR, Tassou A, Matan G, Shirvan S, Hill RZ, Scherrer G, O’Brien LL. 2024. Comprehensive mapping of sensory and sympathetic innervation of the developing kidney. Cell Reports. DOI: 10.1016/j.celrep.2024.114860
2023
Honeycutt SE, N’Guetta PY, Hardesty DM, Xiong Y, Cooper SL, Stevenson MJ, O’Brien LL. 2023. Netrin-1 directs vascular patterning and maturity in the developing kidney. Development. doi: 10.1242/dev.201886
N’Guetta PY, O’Brien LL. 2023. Cover Image_NDT. Nephrology Dialysis Hypertension. Volume 38, Issue 10. ISSN 0931-0509
Stevenson MJ, Phanor SK, Patel U, Gisselbrecht SS, Bulyk ML, O’Brien LL. 2023. Altered binding affinity of SIX1-Q177R correlates with enhanced WNT5A and WNT pathway effector expression in Wilms tumor. Dis Model Mech. doi: 10.1242/dmm.050208
Gerlach GF, Imseis ZH, Cooper SL, Santos AN, O’Brien LL. 2023. Mapping of the podocin proximity-dependent proteome reveals novel components of the kidney podocyte foot process. Front Cell Dev Biol. doi:10.3389/fcell.2023.1195037
2022
Honeycutt S.E., N’Guetta P.Y. and O’Brien L.L., 2022. Innervation in organogenesis. Current Topics in Developmental Biology. Elsevier. https://doi.org/10.1016/bs.ctdb.2022.02.0042021
Ide S, Ide K, Abe K, Kobayashi Y, Kitai H, McKey J, Strausser SA, O’Brien L.L., Tata A, Tata PR, Souma T., 2022. Sex differences in resilience to ferroptosis underlie sexual dimorphism in kidney injury and repair. Cell Rep. doi:10.1016/j.celrep.2022.111610.
2021
Honeycutt S.E. and O’Brien L.L. 2021. Injection of Evans blue dye to fluorescently label and image intact vasculature. Biotechniques. doi: 10.2144/btn-2020-0152.
Ide S, Kobayashi Y, Ide K, Strausser SA, Abe K, Herbek S, O’Brien L.L., Crowley SD, Barisoni L, Tata A, Tata PR, Souma T., 2021. Ferroptotic stress promotes the accumulation of pro-inflammatory proximal tubular cells in maladaptive renal repair. Elife. doi: 10.7554/eLife.68603
2019 et al.
O’Brien, L.L. 2019. Nephron progenitor cell commitment: Striking the right balance. Sem. Cell Dev. Biol. S1084-9521(17)30421-4.
O’Brien, L.L., Combes, A.N., Short, K.M., Lindström, N.O., Whitney, P.H., Cullen-McEwen, L.A., Ju, A., Abdelhalim, A., Michos, O., Bertram, J.F., Smyth, I.M., Little, M.H., and A.P. McMahon. Wnt11 directs nephron progenitor polarity and motile behavior ultimately determining nephron endowment. eLIFE. 7. pii: e40392. doi: 10.7554/eLife.40392.
O’Brien, L.L., Guo, Q., Bahrami-Samani, E., Park, J.-S., Hasso, S.M., Lee, Y.J., Fang, A., Kim, A.D., Guo, J., Hong, T.M., Peterson, K.A., Lozanoff, S., Raviram, R., Ren, B., Fogelgren, B., Smith, A.D., Valouev, A., and A.P. McMahon. 2018. Transcriptional regulatory control of mammalian nephron progenitors revealed by multi-factor cistromic analysis and genetic studies. PLOS Genetics. 14:e1007181.
O’Brien, L.L., Guo, Q., Lee, Y.J., Benazet, J.D., Tran, T., Whitney, P.H., Valouev, A., and A.P. McMahon. 2016. Differential regulation of mouse and human nephron progenitors by the Six-family transcriptional regulators. Development. 143:595-608.
O’Brien, L.L. and A.P. McMahon. 2014. Induction and patterning of the metanephric nephron. Sem. Cell Dev. Biol. 36:31-8.
O’Brien, L.L. and A.P. McMahon. 2013. Progenitor programming in mammalian nephrogenesis. Nephrology. 18:177-179.
Park, J.-S., Ma. W., O’Brien, L.L., Chung, E., Guo, J.J., Cheng, J.G., Valerius, M.T., McMahon, J.A., Wong, W.H., and A.P. McMahon. 2012. Six2 and Wnt regulate self-renewal and commitment of nephron progenitors through shared gene regulatory networks. Dev. Cell. 23: 637-651.
O’Brien, L.L., Grimaldi, M.J., Kostun, Z., Wingert, R.A., Selleck, R., and A.J. Davidson. 2011. Wt1a, foxc1a, and the Notch mediator rbpj physically interact and regulate the formation of podocytes in zebrafish. Dev. Biol. 358: 318-330.
Woolner, S., O’Brien, L.L., Wiese, C., and W.M. Bement. 2008. Myosin-10 and actin filaments are essential for mitotic spindle function. J. Cell Biol. 182: 77-88.
O’Brien, L.L. and C. Wiese. 2006. TPX2 is required for postmitotic nuclear assembly in cell-free Xenopus laevis egg extracts. J. Cell Biol. 173: 685-694.
Wiese, C. and L.L. O’Brien. 2006. What’s so Bor(a)ing about Aurora-A activation? Dev. Cell. 11: 133-134.
O’Brien, L.L., Albee, A.J., Liu, L., Tao, W., Dobrzyn, P., Lizarraga, S.B., and C. Wiese. 2005. The Xenopus TACC homologue, maskin, functions in mitotic spindle assembly. Mol. Biol. Cell 16: 2836-2847.